Sildenafil Citrate (the underlying chemical for the brand name drug Viagra, Revatio, and other various drug names), is a PDE5 inhibitor that is marketed in pill form to treat erectile dysfunction and pulmonary arterial hypertension. The drug was originally developed by British scientists before being brought to market by U.S.-based pharmaceutical giant Pfizer.

Sildenafil citrate was discovered in the 1990’s as a potential treatment for hypertension and hair loss. Scientists discovered that sildenafil citrate had a positive effect in managing erectile dysfunction, and Pfizer brought Viagra to the market in 1998.The drug was an immediate success and pharmaceutical blockbuster. In addition to generic drug manufacturers, the competitors to Viagra Super Active include Eli Lilly’s Cialis, and Bayer’s Levitra.

Buy Viagra super active

Buy Viagra Super Active now

The dosages for Viagra Super Active vary in potency depending upon the severity of the erectile dysfunction. Specifically, Viagra Super Active comes in dosage amounts of 25mg, 50mg, or 100mg, of which the proper amount is to be determined by the prescribing physician. However, most dosages of Viagra Super Active come in the 100mg dosage, so it may be recommended that patients seeking Viagra Super Active also invest in pill cutters to accurately separate the dosages. Like all other erectile dysfunction treatments, Viagra Super Active may cause complications and risks to the patient’s health via drug interactions and prior health ailments of the patient. As such, the taking a dosage amount above the prescription may lead to serious complications and is not recommended. There may be temptation to take a higher dosage than prescribed or take the drug via crushing and inhalation. However, this method of absorbing the active ingredients in Viagra Super Active may lead to heart failure. This may occur because the metabolic process in the stomach and liver break down the active chemical compound in Viagra Super Active and allow the drug to be properly absorbed.

Like all erectile dysfunction drugs, Viagra Super Active works by inhibiting the phosphodiesterase type 5 (PDE5) receptor. Specifically, the enzyme promotes degradation of the cGMP-specific PDE5 receptor, which is directly responsible for the regulation of blood flow to the penis. The PDE5 receptor regulates the smooth muscle cells along the blood vessels in the penis. Naturally, the penis will not be erect when these vessels are not filled with blood. The lack of blood flow even during sexual arousal is the cause of erectile dysfunction. Only when these cells are filled with blood will the penis be erect.

These drugs block the natural degenerative action of these vessels. By blocking the degenerative action caused by the PDE5 receptor blood is allowed to fill these cells and create an erection whether voluntarily or involuntarily. The natural inhibitor of PDE5 is created by the release of nitric oxide in the penile local area, but when there is no or little nitric oxide an erection cannot be obtained. However, it is still recommended the patient takes only the recommended dose at least an hour before desired sexual activity as the drug needs to be properly metabolized by the patient. Even if the patient desires to engage in sexual activity more than once a day, it is not recommended to take this drug before each instance of sexual activity unless approved by the prescribing physician.

The side effects of Viagra Super Active are similar to most erectile dysfunction drugs. The side effects range from common, less severe effects like headache, stomach discomfort, indigestion, burping, acid reflux, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects reflect the ability of PDE5 inhibition to cause vasodilation (the expansion of blood vessels) that may last for a few hours. Because this drug causes vasodilation, greater blood flow increases blood volume and blood pressure to decrease. Patients with low blood pressure or are taking blood thinners (such as statins like Lipitor to treat high cholesterol) may be prescribed lower dosages to prevent possible complications to these pre-existing conditions. If a larger dose of Viagra Super Active is taken by a patient with these pre-existing conditions, more serious side effects like heart failure or hypotension may occur. Furthermore, care should be taken if the patient is HIV positive and is taking protease inhibitors, since these inhibitors inhibit the metabolism of sildenafil, which causes the blood serum levels of sildenafil to be abnormally high. Some physicians will recommend a patient only take 25mg every 48 hours to prevent this complication. Other drugs that interfere with the metabolism of sildenafil include erythromycin (an antibiotic) and cimetidine (used to treat heartburn). Even consuming alcohol while taking Viagra Super Active is not recommended as ethanol is a blood thinner.

Leave a Reply